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ZOLEDRONIC ACID
CAS: 118072-93-8 (165800-06-6)
Status: In development
Business unit: R&D Ofichem
Status: In development
Business unit: R&D Ofichem
Laboratorium Ofichem BV
N/A
Information
Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.
Bisphosphonates are taken into the bone where they bind to hydroxyapatite. Bone resorption by osteoclasts causes local acidification, releasing the bisphosphonate, which is taken into the osteoclast by fluid-phase endocytosis. Endocytic vesicles become acidified, releasing bisphosphonates into the cytosol of osteoclasts where they act.
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