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DIMETHYL FUMARATE
CAS: 624-49-7
Business unit: Lab Ofichem
Business unit: Lab Ofichem
Laboratorium Ofichem BV
DMF-US / DMF-EU
Information
Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress.
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